Micro RNA ‐483 amelioration of experimental pulmonary hypertension
نویسندگان
چکیده
منابع مشابه
Evaluation of Pulmonary Hypertension In First Degree Relatives Of Patients With Primary Pulmonary Hypertension
Background: Pulmonary hypertension (PH) was defined for the first time in 1951 as primary pulmonary hypertension (PPH). Some studies emphasized on the role of genetics in the development of pulmonary hypertension in family members of affected patients. So, in this study we evaluated the prevalence of pulmonary hypertension in first degree family of patients with documented PPH. Methods: In thi...
متن کاملExperimental Acute Monolobar Pulmonary Hypertension †
Necrosis, fibrinoid changes, and cellular infiltrations of pulmonary arterioles have been observed, among other alterations, in extreme pulmonary arterial hypertension. Whether these lesions are the cause or the effect of the high pressure, whether they are the consequence of spasm, or whether they are produced by some other mechanism such as hypersensitivity, remains to be established. Certain...
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Over the last years, small non-coding microRNAs (miRNAs) have emerged as central actors of PAH etiology. Strong miRNA expression disorders occur in lungs as well as in right ventricle (RV) of PAH patients, which respectively lead to vascular remodeling of the distal pulmonary arteries and to RV failure. On the other hand, our understanding of PAH physiopathology has recently increased with the ...
متن کاملThalassemia Associated Pulmonary Hypertension
Cardiac disease is the main cause of death in both forms of thalassemia; thalassemia major (TM) and thalassemia intermedia (TI). Pulmonary hypertension (PH) is one of the cardiopulmonary morbidities with high mortality that, if not treated, may trigger right-sided heart failure and premature death. PH is defined as a mean pulmonary artery pressure of ≥25 mmHg at rest or ≥30 mmHg during exercise...
متن کاملHandoko – RV-pacing in experimental pulmonary hypertension
21 Right heart failure in pulmonary arterial hypertension (PH) is associated with mechanical 22 ventricular dyssynchrony, which leads to impaired right ventricular (RV) function, and by 23 adverse diastolic interaction to impaired left ventricular (LV) function as well. However, 24 therapies aiming to restore synchrony by pacing are currently not available. In this proof-of25 principle study, w...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2020
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201911303